My research strives to develop appropriate technology-based solutions to address important issues that challenge HIV-infected patients both in resource-poor settings and the United States.
We are interested in developing new or improved catalytic materials by studying how the structure of a catalyst affects its performance in a chemical reaction.
As a clinician scientist, Dr. Cui and his research team will create an optimal deliverable bone graft substitute to enhance bone repair and to provide novel treatement for osteonecrosis and osteolysis.
We explore the molecular mechanisms of the pathogenesis of the obligate human pathogen Neisseria gonorrhoeae. The insights gleaned from these studies will facilitate our understanding of how the innate immune system defends against infection, how pathogens exploit mucosal defenses to aid in colonization and transmission, and how the structure-function relationship of pathogen-associated surface proteins modulates the infection process.
The research programs in Professor Campbell’s group, Photonic Devices, focus on photodetectors. At present he is actively involved in single-photon-counting APDs, Si-based optoelectronics, high-speed low-noise avalanche photodiodes, high-power high-linearity photodiodes, ultraviolet analanche photodiodes, and solar cells.
Ben Calhoun's research focuses on low-power VLSI design. Specifically, he is interested in ultra-low energy circuits operating in the sub-threshold region (with VDD less than VT). He also researches the impact of process scaling on memory circuits and architectures.
We are undertaking a new initiative to examine how DNA is released from the icosahedral capsid to initiate an infection. DNA release or uncoating is being studied beginning with purified DNA-containing capsids and an in vitro uncoating system recently developed in our laboratory. Experiments are carried out to identify the DNA end that emerges first from the capsid and to clarify the nature of heterogeneity observed in the population of DNA-containing capsids. In vitro studies are being complemented with an analysis of DNA uncoating as it occurs in infected cells.
Our laboratory is involved with developing magnetic resonance (MR) techniques as a tool for basic biomedical research. We have developed noninvasive, non-contrast-enhanced methods for imaging blood perfusion, demonstrated to be effective in imaging blood flow to the kidneys, lungs, heart, and brain in humans. We were also the first to demonstrate the feasibility of imaging the lung using hydrogen-based MR methods.