Most of the information encoded within the genome of a human or of a bacteria is ultimately expressed as the linear sequence of amino acids in an expressed protein. This sequence determines, within the environment of that organism, the structure(s) of that protein. In turn, this structure(s) determines the interactions and functions of the protein. As we learn more of how sequences determine structures, we better understand how the genome guides physiology.
His objective is to find new approaches in the development of advanced light microscopy and optoelectronic devices. These will allow studying and monitoring various biological and clinical systems ranging from a single cell to single molecule in living cells and tissues. In vivo imaging is another ideal device he is developing to monitor the cellular behavior in the brain of an animal.