Terahertz (THz) vibrational spectroscopy is an emerging technique for characterization and fingerprinting of biological and organic materials. The new proposed approach  for coupling between  THz radiation and biomaterials allows for dramatic improvements in sensitivity, reliability, and selectivity of terahertz spectroscopic sensors  with only nanograms of material required for sampling. Integrating the developed spectroscopic instrument with a microfluidic platform will open the way for monitoring interactions between biomaterials and reagents, for studying conformational change and biomedical processes in a near real-time.